Cooling Solutions: Industrial Chillers in Pharma

I. 4 Reasons Why Industrial Chillers are Essential in Pharmaceuticals


●Ensure the stability of drugs

Industrial chiller as an advanced temperature control equipment for the pharmaceutical industry temperature control has brought great convenience and advantages. Many drugs are particularly sensitive to temperature. If the temperature is too high during the pharmaceutical process, it may lead to decomposition, degradation, or inactivation of the drug, while low temperature may lead to crystallization or crystallization of the drug. By using an industrial chiller, the temperature during the manufacturing process can be precisely controlled to ensure that the drug is within a stable temperature range, thus maintaining the quality and effectiveness of the product.


●Controlling the reaction rate of a drug

Generally, the reaction rate of a drug is positively correlated with the temperature. The higher the temperature will cause the reaction rate to be too fast; the lower the temperature will cause the reaction rate to be too slow; the reaction rate is too fast or too slow will lead to the formation of by-products and waste. Therefore, the use of an industrial chiller to control the temperature of the pharmaceutical reaction process can effectively improve product purity and reduce unnecessary waste.


●Cooling reaction equipment

The pharmaceutical reaction process will emit a large amount of heat, if you do not use an industrial chiller timely and effective discharge of this heat, the reaction equipment overheating will not only affect the product quality and production capacity but also damage the reaction equipment, which will not only increase the cost of maintenance of the enterprise but also affect the production schedule of the pharmaceutical companies. In addition, it will not be able to deliver customer orders on time, thus affecting the reputation of the enterprise and customer relations and increasing economic losses.


●Improve safety

Certain reactions may produce explosions, combustion, or exothermic reactions at high temperatures. By using an industrial chiller to effectively control the temperature of the pharmaceutical reaction process, you can avoid the dangers caused by a sudden increase in temperature, such as casualties, equipment damage, environmental pollution, and legal liability.


II. Water Cooled Screw Chiller vs. Air Cooled Screw Chiller

Unlike other industries, many reactions in the pharmaceutical process need to be carried out at low temperatures to ensure the high purity and quality of the pharmaceutical products. Therefore, traditional industrial chillers are unable to meet the requirements of the pharmaceutical process for a low-temperature environment. In this case, we recommend pharmaceutical companies to use low-temperature screw chillers, which are capable of providing the required low-temperature cooling effect.

Water-cooled screw chillers

The cooling water system in pharmaceutical equipment is connected to the condenser and evaporator of the chiller through pipes. The cooling water realizes the heat exchange of the cooling system, i.e., the cooling water absorbs the heat generated by the screw compressor and the heat released by the coolant in the condenser as it flows inside the screw chiller so that the temperature of the pharmaceutical equipment can be lowered and the cooling effect is realized. Generally, low-temperature screw chillers can provide a low water discharge temperature, usually between 0°C and -45°C. However, it should be noted that the lowest water discharge temperature is between 0°C and -45°C, which is the same as the lowest water discharge temperature. However, it should be noted that the minimum outlet temperature depends on several factors, such as refrigerant type, cooling circulating water temperature, etc.


Air-cooled screw chillers

Air-cooled screw chillers utilize a built-in fan to dissipate heat from the compressor and condenser, thereby lowering the temperature of pharmaceutical equipment. The air-cooled screw chiller can be directly installed outdoors without the need to configure an additional machine room, which effectively avoids the additional costs required for the construction and maintenance of the machine room.


III. Air cooled chiller& Water cooled chiller Maintenance Checklists

●Observe the oil level of the compressor

The lubricating oil plays a key role in the lubrication and sealing of the compressor in the chiller. Generally, the compressor oil level should be located in the middle of the oil window or oil level mark. A low oil level may lead to insufficient lubrication, increase mechanical wear and friction, and even cause overheating and malfunction. On the contrary, too high an oil level may lead to excessive lubrication, affecting the operating efficiency of the compressor and thus the cooling effect of the chiller.


●Regular replacement of lubricating oil

Generally, lubricating oil needs to be replaced regularly every 3-6 months. Dirty lubricating oil will block the oil circuit and filter, affecting the normal operation of the lubrication system, thus affecting the cooling effect of the chiller, and even affecting the equipment failure and damage.


●Clean up the fan

For air-cooled screw chillers, the fan plays a vital role in the cooling system's heat dissipation. Therefore, we need to clean the fan regularly to avoid the accumulation of excessive dust, dirt, and other impurities on the surface of the fan, hindering the distribution of heat, and thus affecting the cooling effect of the chiller.


To summarize, the industrial chiller has an indispensable position and important role in the pharmaceutical field. It is widely used in pharmaceutical synthesis, hydrolysis, etherification, and other reaction processes for maintaining precise reaction temperatures, improving product quality and purity, increasing production efficiency, and increasing the safety of the pharmaceutical process. Kassel Machinery, as the world's top chiller manufacturer in the pharmaceutical field, has established long-term relationships with top pharmaceutical companies at home and abroad. We focus on providing professional, customized cooling solutions based on our customers' needs.

Post time:Sep-25-2020

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